| EPSRC Reference: |
GR/L07161/01 |
| Title: |
CHIRAL BASE CHEMISTRY: ADVANCES IN BASE DESIGN AND SYNTHESIS APPLICATIONS |
| Principal Investigator: |
Simpkins, Professor NS |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 March 1997 |
Ends: |
31 August 1999 |
Value (£): |
94,775
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Summary on Grant Application Form |
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The aim of the proposed work are to advance our studies in the area of chiral lithium amide base chemistry. We seek to improve the fundamental understanding of these reactions, which in turn will allow us to develop more selective and powerful bases, and to broaden the applications of the chemistry to new and novel transformations. The proposed work involves an NMR study of chiral bases in order to clarify aggregation phenomena and salt effects, and to predict the likelihood of non-linear effects in chiral lithium amide mediated reactions. A new family of 1, 2-diamine bases will be synthesised and tested, preliminary results have shown that a single member of this group of bases shows outsiding promise. The scope and limitations of two unprecentented transformations, involving episulfoxides and phosphine oxides, will be examined, with the aim of developing these reactions into mature parts of the chiral base repertoire. A new and novel type of enantioselective enolisation will be examined as a possible entry to the zaragozic acids.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |