| EPSRC Reference: |
GR/L06232/01 |
| Title: |
EQUILIBRATION AND BITE BACK - POWERFUL ALLIES FOR CONTROL DIASTEREOSELECTIVITY IN RADICAL REACTIONS |
| Principal Investigator: |
Harrowven, Professor DC |
| Other Investigators: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
50,308
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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A procedure has been found to control diastereoselectivity in radical cyclisations involving 1, 6-dienes and mediated by disulfides. Our aim with this programme is to extend the scope of the reaction to other dienes and reactive substrates; to develop intermolecular and asymmetric variants and to apply this technology in target synthesis. Analogous reactions mediated by other heteroatom centred radicals will also be examined. Noteworthy features of this method are 1) that the reactions are simple to perform and clean; 2) employ disulfides which are less toxic and less expensive than trialkylstannanes and 3) retain functionality about newly created carbon to carbon bonds.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |