| EPSRC Reference: |
GR/L04696/01 |
| Title: |
SCOPE DEVELOPMENT AND OPTIMISATION OF POSAM TM COMBICHEM TECHNIQUES AND APPLICATIONS |
| Principal Investigator: |
Gani, Professor D |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Unknown |
| Organisation: |
University of St Andrews |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
30 April 1997 |
Ends: |
30 September 1998 |
Value (£): |
57,940
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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In the recent past we have developed and built a semi-automatic synthesiser that is capable of performing Permutational Organic Synthesis in Addressable Microreactors (POSAMTM). The synthesiser has the capacity to perform 300 (upgradable to 600) reactions at a time and can provide up to 10 mg of each product in this mode for compound library members of ca 500 Da. Using conventional resins for peptide synthesis, cycle yields are close to 100%. The entire synthesiser was designed specifically for POSAMTM and all wetted components are inert and suitable for more demanding and harsh reaction conditions. Here we request support to use our leading position in reactor design to tackle the difficult but highly important C-C bond formation reactions. Note that patents covering all aspects of the design of the synthesiser have been applied for (by the University of St Andrews) and that the full automation of the POSAMTM synthesiser will be performed in collaboration with a commercial organisation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.st-and.ac.uk |