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Details of Grant 

EPSRC Reference: GR/K93341/01
Title: ROPA NEW LINKERS FOR THE DIRECT BIOLOGICAL ASSAY OF COMBINATORIAL LIBRARIES
Principal Investigator: Bradley, Professor M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Southampton
Scheme: ROPA
Starts: 03 February 1997 Ends: 02 August 1998 Value (£): 80,956
EPSRC Research Topic Classifications:
Combinatorial Chemistry
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:  
Summary on Grant Application Form
Linkers play a pivotal role in combinatorial chemistry. However the harsh and biologically incompatible cleavage conditions associated with traditional linkers are required which can be cleaved using a variety of biologically friendly methods. Ideally allowing compound release into free solution or into agarose gels ready for direct biological testing as well as keeping all by-products resin bound. The proposal describes the synthesis of a new of new linkers which would allow compound release following safety catch activation either by an intramolecular (catalysed) cleavage process, by the use of a highly efficient light cleavage or by thermal activation.
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Organisation Website: http://www.soton.ac.uk