EPSRC Reference: |
GR/K93341/01 |
Title: |
ROPA NEW LINKERS FOR THE DIRECT BIOLOGICAL ASSAY OF COMBINATORIAL LIBRARIES |
Principal Investigator: |
Bradley, Professor M |
Other Investigators: |
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Researcher Co-Investigators: |
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Project Partners: |
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Department: |
Sch of Chemistry |
Organisation: |
University of Southampton |
Scheme: |
ROPA |
Starts: |
03 February 1997 |
Ends: |
02 August 1998 |
Value (£): |
80,956
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EPSRC Research Topic Classifications: |
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EPSRC Industrial Sector Classifications: |
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Related Grants: |
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Panel History: |
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Summary on Grant Application Form |
Linkers play a pivotal role in combinatorial chemistry. However the harsh and biologically incompatible cleavage conditions associated with traditional linkers are required which can be cleaved using a variety of biologically friendly methods. Ideally allowing compound release into free solution or into agarose gels ready for direct biological testing as well as keeping all by-products resin bound. The proposal describes the synthesis of a new of new linkers which would allow compound release following safety catch activation either by an intramolecular (catalysed) cleavage process, by the use of a highly efficient light cleavage or by thermal activation.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
Description |
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Summary |
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Date Materialised |
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Sectors submitted by the Researcher |
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Project URL: |
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Further Information: |
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Organisation Website: |
http://www.soton.ac.uk |