| EPSRC Reference: |
GR/K89788/02 |
| Title: |
SYNTHESIS OF MECHANISM-BASED INHIBITORS AND PROBES FOR INOSITOL MONOPHOSPHATASE |
| Principal Investigator: |
Gani, Professor D |
| Other Investigators: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Birmingham |
| Scheme: |
ROPA |
| Starts: |
01 October 1998 |
Ends: |
30 June 2001 |
Value (£): |
38,296
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The mechanism and structure of inositol monophosphatase, the putative target for lithium therapy, have been determined recently in our laboratory. A new range of mechanism-based inhibitors for inositol monophosphates will be synthesised by elaboration of 06-(2' -hydroxyethyl)-cyclohexane-1,2,4,6-tetraol phosphates and cyclic phosphates using methodologies starting from (-)-quinic acid. The compounds will be tested and the results will be used to test our understanding and to design and prepare highly specific compounds of potential medicinal value.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |