| EPSRC Reference: |
GR/K88187/01 |
| Title: |
APPLICATION OF OLEFIN METATHESIS TO THE SYNTHESIS AND MODIFICATION OF AMINO ACIDS AND PEPTIDES |
| Principal Investigator: |
Gibson, Professor SE |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
10 February 1997 |
Ends: |
09 February 1999 |
Value (£): |
103,758
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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One of the major objectives in transition metal-catalysed olefin metathesis research at present is to understand the factors that control the cross metathesis of functionalised alkenes so that conditions and catalysts can be developed which facilitate the use of this reaction in organic synthesis. This objective is worthwhile as success would provide synthetic organic chemists with a strategically new and attractive alkene synthesis. In view of the current high levels of industrial and academic interest in amino acids and peptides, we propose to undertake cross metatheseis studies using unsaturated amino acids as substrates. In order to demonstrate the methodology we develop, we propose to apply it to the synthesis of several biologically active amino acids and to prove its potential for the modification of peptides both in a tradition and combinatorial sense.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |