| EPSRC Reference: |
GR/K87364/01 |
| Title: |
NEW CATALYSTS FOR THE ASYMMETRIC REDUCTION OF CARBONYL GROUPS |
| Principal Investigator: |
Wills, Professor M |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of Warwick |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1995 |
Ends: |
31 January 1998 |
Value (£): |
100,233
|
| EPSRC Research Topic Classifications: |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Preliminary studies in our group have led to the identification of a new class of catalyst for the asymmetric reduction of ketones. Several structural variants of the catalyst have been prepared, which have in common either a N-P=O or N-P=N structural unit, which is essential for catalytic activity. Enantiomeric excesses achieved to date have been modest. However, the rate of the catalysed reaction is critically dependant on the geometry of the catalyst and this observation has aided the design of an optimum catalyst which will be prepared and utilised in this propect. A range of substrate ketones will be employed in the project, many of which form the basis for the synthesis of complex natural products and synthetic intermediates.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.warwick.ac.uk |