Details of Grant 

EPSRC Reference:	GR/K87326/01
Title:	OPTIMISATION OF BIOMATERIAL SURFACES FOR BONE REPAIR
Principal Investigator:	Grant, Professor DM
Other Investigators:
Researcher Co-Investigators:
Project Partners:	Pre Nexus Migration
Department:	Sch of Biomedical Sciences
Organisation:	University of Nottingham
Scheme:	LINK
Starts:	01 September 1996	Ends:	31 October 1999	Value (£):	259,121
EPSRC Research Topic Classifications:	Materials Processing
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
A wide range of materials are used in the manufacture of prostheses. This combined with the diversity of surface treatments available, from continuous to porous coatings, surface modification of structure and topography means a diversity of cellular response occurs. The cellular responses are dependent on a range of parameters including, topography, surface structure and orientation, stoichiometric changes, surface changes and surface chemistry. These parameters will be targeted systematically by determining precise cellular and molecular interactions on selected material surfaces, so that these parameters may be separated out. Collaborators will supply the range of initial materials. Briefly, processes involving protein adsorption, cell attachment, clustering of cell membrane receptors and assembly of the cytoskeletal complexes will be mapped. Surface characterisation by AFM, SEM, ESCA, TEM, XRD, ETIR will be performed on these surfaces. Identified parameters will be pursued by surface modifications performed in house or by the Industrial Collaborators. These results will provide vital data for the prosthesis manufacturers. A rapid screening technique will be developed to provide manufacturers with the essential feedback they require for optimising and modifying surfaces.
Key Findings
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Organisation Website:	http://www.nottingham.ac.uk