| EPSRC Reference: |
GR/K82284/01 |
| Title: |
SELENIUM BASED REAGENTS FOR CATALYTIC ASYMMETRIC OXIDATION |
| Principal Investigator: |
Donohoe, Professor T |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1996 |
Ends: |
31 March 2000 |
Value (£): |
6,396
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Summary on Grant Application Form |
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The allylic oxidation of olefins as mediated by selenium dioxide, is a powerful and reliable synthetic reaction which provides unique and expeditious method of introducing oxygen into a substrate molecule. The aim of this proposal is to develop a method for performing an asymmetric allylic oxidation by using chiral (non-racemic) selenium-containing oxidants so as to produce enantiopure allylic alchohols. We have access to a wide variety of structurally diverse oxidants and this, together with an understanding of the mechanism of allylic oxidation, may allow us to develop a viable method of enantioselective oxidation. Moreover, this protocol has the added advantages that: I) it can be made to be catalytic in selenium species so that only small amounts need to be used, ii) the catalyst may be covalently attached to a polymer thus allowing efficient recovery of the selenium species and reducing the amount of toxic by products from the oxidation.Oxidation, Catalytic, Organic, Chemistry, Asymmetric, Mechanism, Selenium, Methodology, Polymers.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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Sectors submitted by the Researcher |
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