| EPSRC Reference: |
GR/K76092/01 |
| Title: |
ENANTIOSELECTIVE HYDROGENATION OF SUBSTITUTED PYRIDINES |
| Principal Investigator: |
Wells, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Hull |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 1995 |
Ends: |
31 October 1998 |
Value (£): |
172,383
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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| Panel History: |
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Summary on Grant Application Form |
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In this collaborative project with Hickson Fine Chemicals novel heterogeneous catalysts will be designed, prepared, and evaluated for the enantioselective hydrogenation of substituted pyridines to chiral piperidines. Three types of catalyst will be researched, in each of which a metallic active phase (most probably Pd) will function in the chiral environment provided either by an adsorbed modifier (alkaloid or carbohydrate) or by an optically active support Catalyst optimisation will require a knowledge of the physical properties of the catalysts, the manner in which they adsorb modifiers and reactants, the interaction of modifier with reactant, and the mechanisms of hydrogenation. Successful reactions which have been optimised with respect to enantiomeric excess in the Hull laboratory will be scaled-up at Hickson's within the grant programme. The Comapny will consider adding chiral piperidines to its product range as a result of this research.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hull.ac.uk |