| EPSRC Reference: |
GR/K75934/01 |
| Title: |
CATALYTIC ASYMMETRIC SYNTHESIS OF EPOXIDES AND AZIRIDINES |
| Principal Investigator: |
Aggarwal, Professor VK |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 1995 |
Ends: |
31 August 1999 |
Value (£): |
293,562
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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Summary on Grant Application Form |
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We have discovered a conceptually different method for preparing non-racemic epoxides which requires just catalytic amounts of sulfides and metal salts and stoichiometric amounts of aldehydes and diazocompounds. In this process atom effiicency is high since we are carrying out C-C and 2 x C-X bonds simultaneously. Conventional chemistry relies on oxidation of alkenes which are themselves prepared by Wittig chemistry. Our method obviates the need for Wittig chemistry and the associated problems with removing phosphine oxides. We now wish to improve the enantioselectivity, diastereoselectivity and turnover in the process for epoxidation and attempt to generalise the method to aziridination. Success in aziridination would provide probably the most versatile and general method for preparing this class of compounds in enantiomericlaly enriched form and under exceptionally clean conditions. We then wish to explore alternative diazocompounds and apply our new technology to the asymmetric synthesis of industrially important targets.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |