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Details of Grant 

EPSRC Reference: GR/K75828/01
Title: CATALYTIC HYDROGEN SHUTTLES.A ZERO WASTE APPROACH TO GENERIC FUNCTIONALITY
Principal Investigator: Grigg, Professor R
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Leeds
Scheme: Standard Research (Pre-FEC)
Starts: 23 November 1995 Ends: 22 May 1999 Value (£): 169,286
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
Chemicals
Related Grants:
Panel History:  
Summary on Grant Application Form
Catalytic hydrogen shuttles will be developed, via cascade reaction design, to provide rapid access to a range of generic functionality, heterocycles and novel alpha-amino acids. The catalytic hydrogen shuttles are designed to produce no by-products other than water and to operate in closed catalytic cycles that employ readily available starting materials.Thus the catalytic hydrogen shuttle N-alkylation of amines by alcohols offers considerable advantages over current technology and will provide, inter alia, routes to chiral benzylic amines, generic functionality of great industrial importance. Similar shuttles will provide alpha-alkylated aryl acetic acids and alpha-alkylated aryloxyacetic acids, currently widely used as non-steriodal anti-inflammatory agents and weed killers respectively, and related shuttles will furnish novel alpha-amino acids. The project will also seek to develop new high activity homo- and hetero-geneous catalysts and explore immobilisation of catalysts on glass beads. The promoting effects of additives such as NaOH, NR4OH, Cu(I) and Ag(I) salts will be studied. Catalysts identified for particular study are complexes of Rh(I), Ir(I) and Ru(II) and their heterogeneous counterparts. When active catalysts are to hand the focus will switch to the design and evaluation of chiral catalysts.
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Organisation Website: http://www.leeds.ac.uk