| EPSRC Reference: |
GR/K71394/02 |
| Title: |
MATHEMATICAL MODELLING OF SCAR TISSUE FORMATION |
| Principal Investigator: |
Sherratt, Professor JA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
S of Mathematical and Computer Sciences |
| Organisation: |
Heriot-Watt University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1998 |
Ends: |
19 June 1999 |
Value (£): |
69,957
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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We propose the development of a mathematical model for scar formation. The model will build on recent experimental advances, which have clarified the biochemical differences that cause wounds in foetal animals to heal perfectly, while adult wounds scar. These biological advances imply that the model must contain features leading to novel mathematics, in particular the existence of a contuous range of healed states. It is this novel mathematics that provides the central motivation for the research. We will study the model both analytically and numerically, leading to formulae for the speed of healing and the final healed state, as a function of biological parameters. In particular, model predictions will confirm and extend experimental results on the reduction of scarring by chemical intervention. We will go on to consider the effect of wound shape on scarring and speed of healing, and the way in which the shape changes during the healing process. These mathematical conclusions will translate into practical ways of reducing scarring following trauma or surgery.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hw.ac.uk |