| EPSRC Reference: |
GR/K59019/02 |
| Title: |
NMR STUDIES OF TRANSFERRINS-COST COLLABORATION- METALLODRUG TARGETTING |
| Principal Investigator: |
Sadler, Professor P |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Edinburgh |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 1996 |
Ends: |
10 September 1998 |
Value (£): |
16,420
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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Summary on Grant Application Form |
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1. The structure and dynamics of serum transferrins (80 kDa), its recombinant lobes, and mutants will be investigated in solution using NMR spectroscopy. 2. Comparison between species (e.g. human, pig, rabbit) and use of 15N and 13C labelled proteins will aid the assignment of resonances. Resonances which can be used as specific probes of the N- and C- lobes will be identified. 3. Processes relevant to receptor- mediated metal ion, proton, and anion uptake and release, including interdomian hinge-bending, will be investigated. Metal ions will include those of physiological, toxicological and andiagnostic importance, including Fe3+ , Al3+, In3+, and Co3+. Both synergistic and non-synergistic anions will be investigated. Binding constants for anions will be determined. 4. Evidence for communication between anion and metal ion binding sites, and the glycan chains will be sought.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ed.ac.uk |