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Details of Grant 

EPSRC Reference: GR/K56360/01
Title: MOLECULAR IMAGING IN DIAMOND (MIDIA)
Principal Investigator: Mainwood, Professor A
Other Investigators:
Collins, Professor AT
Researcher Co-Investigators:
Project Partners:
Pre Nexus Migration
Department: Physics
Organisation: Kings College London
Scheme: LINK
Starts: 01 August 1995 Ends: 31 December 1997 Value (£): 73,107
EPSRC Research Topic Classifications:
Optical Devices & Subsystems
EPSRC Industrial Sector Classifications:
Manufacturing Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Nucleic acid bases and protein absorb UV light of shorter wavelength than 224nm very strongly, while other cell components such as lipids and carbohydrates are transparent in this region. This matches the spectral sensitivity of diamond. We propose to develop diamond detectors of a novel ridge design for use in nucleic acid sequencing and quantitation and tissue imaging. This will eliminate the hazardous radioactive or luminescent tags from many of these processes, with the associated handling and disposal problems. It will allow them to be completed in a few minutes or hours, rather than the days or weeks required at present, and will be a quantitative technique, easily digitised. The detectors will be fabricated from Chemical Vapour Deposition (CVD) diamond films with strips or pixel electrodes. They can detect UV lights and bs, which will allow the imaging of btagged drugs within tissue and UV absorption of the tissue itself to map the distribution of the drugs.
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