Details of Grant 

EPSRC Reference:	GR/K45227/01
Title:	OPEN ACCESS MASS SPECTROMETRY
Principal Investigator:	Kocienski, Professor P
Other Investigators:	Brown, Professor T Langley, Professor GJ
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Chemistry
Organisation:	University of Southampton
Scheme:	Standard Research (Pre-FEC)
Starts:	01 April 1996	Ends:	31 March 1999	Value (£):	212,352
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Summary on Grant Application Form
The need for upgrading the mass spectrometry facilities is pressing, the existing system (GR/E 19763, 01/87-31/12/89) spends less than 20% of its time carrying out high resolution mass measurements (the main reason for which it was purchased). For more than a year it has also failed to meet the sample number demands of the department. Routine, fast turnaround, low resolution mass spectrometry is a high priority within the department for many of the research groups mass spectrometry has become the high rate-limiting step in advancing research and publications. Open access mass spectrometry (OAMS) has already provided the answer to this in industry; the provision of such a system, equipped with electrospray and atmospheric pressure chemical ionisation inlets would fulfil the Departmental requirements for routine LR-MS. Furthermore, the extended mass range afforded by electrospray will allow precise mass measurements of samples whose mass range afforded by electrospray will allow precise mass measurements of samples whose mass exceeds that of the sector instruments, e.g. modified DNA fragments (these require mass precision greater than that provided by MALDI-TOF).Provision of an OAMS system will allow the present high resolution instrument to carry out many more accurate mass measurements and detailed mass spectrometric experiments. Together these will provide a Grade 5 Chemistry department with a grade 5 mass spectrometry facility, capable of EI, CI, FAB, ES, APCI, GCMS and LCMS.
Key Findings
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Potential use in non-academic contexts
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Organisation Website:	http://www.soton.ac.uk