| EPSRC Reference: |
GR/K16135/01 |
| Title: |
EXTNS OF THE COORD CHEM OF AMAVADIN; N-HYDROXYCARBOXYLATE LIGANDS AS OXO-GROUP EQUIV WITH CHIRAL SELECTIVITY |
| Principal Investigator: |
Garner, Professor C D |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
31 March 1996 |
Ends: |
30 March 1999 |
Value (£): |
6,246
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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Summary on Grant Application Form |
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This investigation derives from the structure and reactivity established for the natural product Amavadin, which comprises a 1:2 complex of vanadium (IV) with the ligand S, S-2-hydroxyiminopropionic acid (HIDPAH3). Each ligand binds through two carboxylate groups and a deprotonated N-hydroxy function to give two mutually trans n2-N-O groups, approximately staggered by 90, above and below a roughly square planar arrangement of oxygen atoms. The structural and spectroscopic properties of several different diastereomers of [V(HIDPA)2]n-, n=2 or 1, have shown an electronic/bonding equivalence between two trans h2-N-O groups and one oxo-group. We have already justified this view chemically by the successful synthesis and characterisation of [D-Mo(R,R-HIDPA)(R,S-HIDPA)] - and its enantiomer. The complexes containing two HIDPA ligands have a rich reversible redox chemistry, five chiral centres, and show novel reactivity. The programme seeks to build these results: 9I) to explore the chemistry with other metals; (ii) to characterise the geometry and electronic structure of the complexes using a wide range of modern methodologies; (iii) to develop the reactivity of the systems, monitored by the essential probes of circular dichroism spectroscopy and electrochemistry, to enquire whether the new molecules can serve as catalysts in asymmetric syntheses.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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