| EPSRC Reference: |
GR/K09670/01 |
| Title: |
SYNTHETIC STUDIES WITH OXAZOLE / THIAZOLE-BASED MARINE IONOPHORES:ULAPUALIDES & LISSOCLINSMIDES |
| Principal Investigator: |
Pattenden, Professor G |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 1994 |
Ends: |
30 November 1997 |
Value (£): |
293,433
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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Summary on Grant Application Form |
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1.To carry out a total synthesis of the novel tris-oxazole containing macrolides known as ulapualides (also halichondramides, kabiramides, mycalolides) found in maine nudibranches and sponges.2.To provide unambiguous total syntheses of the lissocinamide family of thiazole-based cyclic peptide ionophores produced by marine tunicates.3.To examine and to rationalise the metal-chelating capabilities of these marine metabolites through direct studies, modelling, and biological profiling.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |