| EPSRC Reference: |
GR/H96218/01 |
| Title: |
ENANTIOMERICALLY PURE CATALYTIC AUXILIARIES AND TETHERS: A NEW CONCEPT FOR ASYMMETRIC CATALYSTS |
| Principal Investigator: |
Williams, Professor JM |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Loughborough University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 1993 |
Ends: |
31 October 1995 |
Value (£): |
78,290
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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Summary on Grant Application Form |
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This proposal considers a new approach to asymmetric catalysis. Substrate molecules will undergo asymmetric reactions when temporarily attached to a homochiral catalytic auxiliary. The auxiliaries will be in equilibrium with the substrate and product, but only used in catalytic amounts. Several related ideas are explored within the proposal.Firstly, the use of an auxiliary which activates the substrate to reaction is considered. This approach is applied to the asymmetric alkylation of amino ester derivatives.Secondly, reagent activation by a catalytic auxiliary is considered for asymmetric epoxidation with novel oxaziridinium reagents.A further category considered is one wherein the reaction is considered for asymmetric epoxidation with novel oxaziridinium reagents.Additionally, the use of homochiral catalytic tethers for intramolecular Diels-Alder reactions is outlined.This proposal considers a wide range of reactions which may be performed asymmetrically, using a novel concept in asymmetric synthesis.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.lboro.ac.uk |