| EPSRC Reference: |
GR/T26979/01 |
| Title: |
Mathematical Virology: Assembly Models for Viral Capsids based on Tiling Theory |
| Principal Investigator: |
Twarock, Professor R |
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| Department: |
Mathematics |
| Organisation: |
University of York |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2005 |
Ends: |
31 January 2008 |
Value (£): |
67,938
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| EPSRC Research Topic Classifications: |
| Algebra & Geometry |
Medical science & disease |
| Non-linear Systems Mathematics |
Theoretical biology |
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Summary on Grant Application Form |
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This research programme in the area of Mathematical Virology considers mathematical models for the assembly of viral capsids, that is shell structures formed from protein subunits that encapsulate the viral genome. Such models are of strong current interest because they constitute important milestones for the understanding of viral replication mechanisms and hence ultimately for the design of anti-viral therapeutics.In this project we exploit a novel mathematical approach in which viral capsids are modeled based on tiling theory. This approach has been shown to cover all experimentally discovered viruses, especially the family of Papovaviridae. This family of viruses is of prime importance for the public health sector because it contains cancer causing viruses, but could not be treated with previous mathematical approaches before. Based on our tiling models, we develop assembly models for viral capsids and study the role of malformation during assembly. As a result of this, we expect to be able to suggest strategies for interference with viral capsid assembly.As expected from an interdisciplinary project, all mathematical results and models will constantly be discussed with biologist experts in the field, and visits to the group of Dr Zlotnick at the Department of Biochemistry and Molecular Biology at the Health Services Center of the University of Oklahoma are planned during the course of the project.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
http://gow.epsrc.ac.uk/ViewGrant.aspx?GrantRef=GR/T26979/01 |
| Further Information: |
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| Organisation Website: |
http://www.york.ac.uk |