| EPSRC Reference: |
GR/T19155/01 |
| Title: |
The Control and Integration of Angiogenesis at the Tissue Level: A Multi-Disciplinary Study |
| Principal Investigator: |
Schor, Dr AM |
| Other Investigators: |
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| Department: |
School of Dentistry |
| Organisation: |
University of Dundee |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 August 2004 |
Ends: |
30 November 2006 |
Value (£): |
380,212
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| EPSRC Research Topic Classifications: |
| Cells |
Instrumentation Eng. & Dev. |
| Non-linear Systems Mathematics |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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Advances in understanding fundamental biological processes and how these go awry in disease are commonly hindered by the intrinsic complexity of the tissue environment. Overcoming this impasse will be significantly facilitated by forging links between biologists and physical scientists. In order to achieve this much needed end, the EPSRC has recently established the Sandpit initiative with a view to promoting such critical interface interactions. One of the principal outcomes of the first Sandpit workshop held in Dundee in December 2003 is a collaborative research programme concerned with developing novel tools (both experimental and theoretical) for enhancing our understanding of the complex interplay of signals controlling new blood vessel formation. This major study will support the multi-disciplinary interaction of biologists, engineers, polymer chemists and mathematicians working in three major UK universities (Dundee, Imperial College London and Nottingham). The Consortium of researchers will be specifically concerned with developing new experimental protocols for unravelling the complex manner by which diverse chemical and physical factors converge to control new blood vessel formation, and mathematical models for handling and interpreting the vast amount of generated experimental data. This interface adventure has the exciting capacity to generate novel and mutually beneficial networks of interaction between apparently disparate scientific disciplines. In addition, as inappropriate blood vessel formation drives the development of many common human pathologies (such as chronic non-healing wounds, cancer and rheumatoid arthritis), it is anticipated that the new insights and research capabilities generated from this collaboration will provide a sound clinical and commercial platform for improving patient management.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.dundee.ac.uk |