| EPSRC Reference: |
GR/T10190/01 |
| Title: |
Magnetic Nano-composites With Novel Miniaturised Separations For A High Throughput Screening of Physicochemical Properites of Drug Candidates |
| Principal Investigator: |
Tsang, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Reading |
| Scheme: |
High Throughput Industrial Sec |
| Starts: |
01 September 2004 |
Ends: |
29 February 2008 |
Value (£): |
31,282
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The main novelty of the proposed research during Dr Tsang's secondment involves physical entrapment of a small quantity of n-octanol droplets as nano-reactors and entrapping protein or enzyme molecules (no covalent linkage that will affect the binding structure) by the porous over-layer of the magnetic composites for the rapid evaluation of physicochemical parameters in aqueous media as a new high throughput method using magnetic separation. This will involve nano-engineering/synthesis of porous coating of tailored pore size, dimensions, surface affinity, volume for the physical storage of solvent droplets and develop instrument(s) & data handling system to acquire these physicochemical parameters (logD & binding constant) of a drug compound by UV-vis (or fluorescent) quantification using magnetic separation in a robot friendly manner.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.rdg.ac.uk |