| EPSRC Reference: |
GR/S87355/01 |
| Title: |
Novel Transformations of Alcohols Using Catalytic Reversible Oxidation |
| Principal Investigator: |
Williams, Professor JM |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 2004 |
Ends: |
30 June 2007 |
Value (£): |
193,654
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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This proposal aims to develop a clean approach to C-C bond formation using the catalytic reversible oxidation of alcohols. Metal hydride catalysts which have arisen from the collaboration of an organic chemist (Williams) with a synthetic inorganic chemist (Whittlesey) will be employed in catalysing atom efficient net alkylation reactions of alcohols in which water is the only by-product. We will investigate the use of stabilised and semi-stabilised carbon-based nucleophiles, which will undergo aldol-type condensation reactions on the intermediate aldehydes, prior to alkene reduction.This novel methodology will similarly be employed in the dehydrogenation of alcohols to aldehydes, which will subsequently undergo in-situ amination to afford alkylated amine products. The use of our metal hydride catalysts for alkene reduction using alcohols rather than more hazardous pressures of H2 will be developed. Extension of this to incorporate a terminal reductant such as borohydride will open up the potential to deracemise secondary alcohols. Asymmetric variants of these reactions will be assessed for their viability.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |