Details of Grant 

EPSRC Reference:	GR/S86464/01
Title:	Development and validation of a model of compression cuff thereapy for the prevention of deep vein thrombosis
Principal Investigator:	Lawford, Professor P
Other Investigators:	Hose, Professor R Woodcock, Professor J Morris, Dr RHJ
Researcher Co-Investigators:	Dr A Narracott
Project Partners:
Department:	Medical Physics
Organisation:	University of Sheffield
Scheme:	Standard Research (Pre-FEC)
Starts:	01 July 2004	Ends:	30 November 2007	Value (£):	327,202
EPSRC Research Topic Classifications:	Animal & human physiology
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
Deep vein thrombosis (dvt) is a significant problem affecting low mobility groups, including some hospital in-patients and long-haul flight air passengers. This research aims to apply newly-developed computational analysis tools to deepen our understanding of the process of dvt and to study the efficiency of compression cuff therapy as a preventative therapy. It features strong interaction between the group developing the software at the University of Sheffield and the most active group in the UK in the in vivo measurement of dvt therapy, at the University of Wales. It uses specialist software developed at Sheffield for the construction of finite element models from medical scan data and for the coupling of solid and fluids analysis codes. Further algorithmic development of this software will be required to improve stability and speed for this challenging application. Particularly in the context of coupled analyses the determination of appropriate boundary conditions is of primary importance. The group in Wales has extensive experience of the measurement of flow in the cardiovascular system in general, and in the deep veins in the leg in particular, using Doppler Ultrasound, and has a lower limb magnetic resonance imaging facility ideal foracquisition of structural anatomical data for the current project. It is anticipated that the development of a robust model of the influence of the external application of transient pressure on the lower limb on venous flow characteristics will lead to the development of improved therapeutic protocols for the prevention of deep vein thrombosis.
Key Findings
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Organisation Website:	http://www.shef.ac.uk