Details of Grant 

EPSRC Reference:	GR/S79404/01
Title:	A new approach to cyclopentadienyl mimics
Principal Investigator:	Russell, Dr CA
Other Investigators:	Green, Professor M
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Bristol
Scheme:	Standard Research (Pre-FEC)
Starts:	14 April 2004	Ends:	13 April 2007	Value (£):	185,170
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals
Related Grants:
Panel History:
Summary on Grant Application Form
The cyclopentadienyl anion, a five-membered carbon ring compound bearing a single negative charge has the ability to bind to and influence reactions at metal centres. The resulting cyclopentadienyl complexes have played an important role in modem inorganic chemistry. Such compounds were initially studied as academic curiosities but have evolved over the last 50 years to find a multitude of applications ranging from catalysis to polymers to anti-cancer therapy. It is known that the replacement of carbon atoms for phosphorus atoms in these rings induces significant changes in the properties of such compounds, but routes towards such phosphorus -substituted species often involve harsh conditions and hence are not readily explicable or adaptable. We seek to develop new controlled synthetic routes towards such phosphorus substituted five-membered ring compounds and explore their properties. A key feature of our proposal lies in the reversal of polarity of the reaction used to bond them to metal centres, i.e., instead of reacting a ligand possessing a negative charge with a metal bearing a positive charge, we will react a positively charged ligand with a negatively charged metal or metalloid species. This will obviate many of the difficulties currently encountered in synthesis of such species and should lead to a new generation of molecules with interesting properties. Our new approach should lead to greater progress in this promising area of chemistry.
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Organisation Website:	http://www.bris.ac.uk