| EPSRC Reference: |
GR/S77967/01 |
| Title: |
Replication with Hydrocolloids:Replicol |
| Principal Investigator: |
Lloyd, Professor AW |
| Other Investigators: |
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| Department: |
Sch of Pharmacy & Biomolecular Sciences |
| Organisation: |
University of Brighton |
| Scheme: |
Faraday (PreFEC) |
| Starts: |
26 July 2004 |
Ends: |
25 July 2005 |
Value (£): |
3,557
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Summary on Grant Application Form |
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Hydrocolloid materials for dental impressions are hand mixed and set by blending a powder and liquid together. Following the impression, there is a high risk of cross infection within the dental team as a result of transfer of bacteria and viral systems in the saliva. Current methods of disinfection are both time consuming and frequently alter the dimensions of the impression materials and are toxic to normal tissue [Hypochlorite and formaldehyde based materials]. The proposed research evaluates two systems for bacteriocidal activity. The two systems are either based on naturally occuring compositions or have very specific action which may be switched on and off by use of light. In addition, an anti-viral effect may be achieved by addition of detergent or by pH variation to the hydrocolloid. While these systems may be presented as powder/liquid to the operator, the second objective is to produce a two paste system which may be dispensed using conventional dental delivery systems. This would obviate the variability in mixing which may occur and further will ensure that the composition is uniform . This is a problem with currently available materials where the component powders tend to settle out under storage conditions. Preliminary formulations have been prepared and the programme will initially develop prototype formulation which contain the bacteriocidal agents. These will then be tested for both physical properties and bacteriocidal activity. Underpinning this will be evaluations of the pH changes which will occur in the mix. Measuements of nitric oxide release using sensors will be carried out and NO transport will be modelled to have a clearer understanding of release of NO from one system. The academic partners provide expertise in formulation characterisation, theoretical modelling of transport processes, effective monitoring by non-invasive means of the interface between impression and mucosa, the viability of bacterial samples and the clinical requirements (particularly handling). The SMEs will provide materials and dispensing systems and monitor performance via clinical workshops with practitioners. They will also provide hardware for one of the bacteriocidal systems
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bton.ac.uk |