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Details of Grant 

EPSRC Reference: GR/S77301/01
Title: Synthetic Studies on the Natural Products FR182877 and Hexacyclinic Acid
Principal Investigator: Clarke, Professor PA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Nottingham
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2004 Ends: 31 December 2005 Value (£): 193,334
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
Using novel reactions and strategies as well as those developed in the group we intend to synthesise the cytotoxic polyketide natural product hexacyclinic acid. The ABC-rings will be formed by use of a Diels-Alder/reductive annulation approach, while the DEF-rings will be constructed by using our transannular iodocyclisation reaction. Application of this strategy to the total synthesis of the related natural product FR182877 and selected novel analogues of these molecules will enable SAR investigations to commence.
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Organisation Website: http://www.nottingham.ac.uk