| EPSRC Reference: |
GR/S77301/01 |
| Title: |
Synthetic Studies on the Natural Products FR182877 and Hexacyclinic Acid |
| Principal Investigator: |
Clarke, Professor PA |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2004 |
Ends: |
31 December 2005 |
Value (£): |
193,334
|
| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Using novel reactions and strategies as well as those developed in the group we intend to synthesise the cytotoxic polyketide natural product hexacyclinic acid. The ABC-rings will be formed by use of a Diels-Alder/reductive annulation approach, while the DEF-rings will be constructed by using our transannular iodocyclisation reaction. Application of this strategy to the total synthesis of the related natural product FR182877 and selected novel analogues of these molecules will enable SAR investigations to commence.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.nottingham.ac.uk |