| EPSRC Reference: |
GR/S76908/01 |
| Title: |
Dynamic combinatorial chemistry |
| Principal Investigator: |
Sherrington, Professor DC |
| Other Investigators: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2004 |
Ends: |
30 September 2007 |
Value (£): |
95,896
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Describe the proposed research using (about 200) words geared to the non-specialist reader.Our previous work has demonstrated that dynamic combinatorial chemistry can be a practical tool for the identification and synthesis of new receptors. We now propose to exploit dynamic combinatorial chemistry further. Using multiply-functionalised building blocks we will specifically target new receptors with levels of complexity that are very hard to handle using alternative approaches. We aim to achieve hydrogen bonding as a recognition motif in water. By exploiting the chirality of the building blocks we hope to be able to discover new enantioselective receptors. We also plan to assess the potential of dynamic combinatorial chemistry for catalyst discovery and synthesis. We will synthesise a new set of metal-ion containing building blocks, and libraries made from mixtures of these and other building blocks will be screened for affinity for a transition state analogue for metal-ion catalysed hydrolysis, oxidation or Diels-Alder reactions. In collaboration with Prof. Sherrington and Dr Cormack we will optimise the use of supported guests as tools for receptor synthesis and isolation. This approach should allow for the large-scale preparation of new receptors even where the guestinduced amplification is relatively inefficient.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |