| EPSRC Reference: |
GR/S76069/01 |
| Title: |
FARADAY: Adsorption enhanced filtration device for fat removal in cardiac surgery - ADENFID |
| Principal Investigator: |
Mikhalovsky, Professor S |
| Other Investigators: |
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| Department: |
Sch of Pharmacy & Biomolecular Sciences |
| Organisation: |
University of Brighton |
| Scheme: |
Faraday (PreFEC) |
| Starts: |
01 April 2004 |
Ends: |
30 September 2005 |
Value (£): |
61,522
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
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Summary on Grant Application Form |
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A filtration device, which removes fat droplets from the extracorporeal blood circuitry of patients undergoing open heart surgery, will be designed and tested. The work programme comprises three major stages.Firstly, analysis of the fat droplets circulating in the extracorporeal system, in terms of their size, chemical composition and physico-chemical properties that could be exploited for their efficient removal, will be carried out.As an engineering problem, removal of fat droplets from blood is similar to the breakdown of oil/water type of emulsions. However, due to the specific requirements of the blood-containing systems, most approaches currently available in other applications, cannot be used in this case. A monolithic filtering device based on activated carbon will be developed for this purpose. It will have a bimodal pore size distribution with large pores (channels) for blood passage and nanopores within the filter body that will adsorb and retain the fat from the droplets.Efficiency of such a device will be achieved by combining the optimal pore and channel size that will be determined in the second stage. Adsorption affinity towards the fat droplets can be enhanced by chemical modification of the surface, and this route will be also explored. Both stages will be carried concurrently.The third stage will focus on the animal model work in order to investigate the effectiveness and haemocompatibility of the adsorption/fittration technology. It will use a unique rodent model of cardiopulmonary bypass developed by the lead RO.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bton.ac.uk |