| EPSRC Reference: |
GR/S68095/01 |
| Title: |
Cost D25 Support: Biocatalytic Asymmetric Aldol Reactions |
| Principal Investigator: |
Gouverneur, Professor V |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
20 February 2004 |
Ends: |
19 February 2007 |
Value (£): |
17,968
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Bioprocess Engineering |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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While our mechanistic understanding of naturally occurring Diels-Alder is still in its infancy, more information on protein-catalysed [4+2] additions has been obtained with catalytic antibodies. Several Diels-Alderase antibodies have been generated from synthetic haptens mimicking more often the highly ordered transition state of Diels-Alder reactions. Surprisingly, only one example of antibody-mediated hetero Diels-Alder (HAD) reaction of carbonyl compounds has been reported despite the enormous synthetic potential of this particular transformation. The proposed work describes the development of a novel highly enantioselective antibody-route to access hetero Diels-Alder adducts of carbonyl compounds that we expect might be amenable to the preparation of various synthetic intermediates for natural product synthesis. A set of experiments is designed to define the scope of this novel methodology based on a tandem antibody-catalysed Mukayama-type aldol reaction followed by an intramolecular Michael addition. One of the major strand of the COSTcollaboration involves the necessary expertise of other members into mechanistic enzymology as mandatory for improved biocatalyst design, development and application.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |