| EPSRC Reference: |
GR/S60389/02 |
| Title: |
Radiocopper complexes for imaging & treatment of hypoxic tissues |
| Principal Investigator: |
Blower, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Imaging & Biomedical Engineering |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2006 |
Ends: |
30 November 2007 |
Value (£): |
192,698
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Drug Formulation & Delivery |
| Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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Shortage of oxygen (hypoxia) in tissues occurs in many diseases. It is one of the main causes of cancer treatment failure. A reliable imaging procedure to detect hypoxia, such as PET, would represent a major clinical advance, helping to locate disease within the body, plan treatments, and predict outcomes in oncology, cardiology and neurology. These different clinical contexts will require hypoxia targeting agents tuned to have subtly different in vivo properties, targeting different oxygen levels. In this project we will provide these imaging agents by modifying the prototype agent CuATSM, which is taken up specifically in hypoxic cells, to develop a range of radioactive imaging agents individually optimised for the different uses. We will also develop a new type of treatment for use alongside conventional therapies, in which hypoxia-targeted radioisotopes kill resistant hypoxic cancer cells. To achieve this, a mufti-disciplinary effort is planned at a cost of approximately 300k, to develop production of the radioisotope Cu-64 (radiochemistry, St Thomas' Hospital, London), synthesise a large number of complexes from which to choose those with the best properties (synthetic chemistry, University of Kent), and measure the relevant properties in cultured cancer cells (analytical chemistry and radiobiology, University of Kent). The new products will be tested in vivo by collaboration with groups at Royal Free Hospital. London. and Washington University. St. Louis. USA.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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