Details of Grant 

EPSRC Reference:	GR/S54692/01
Title:	Quatitative medical optical tomography using a priori anatomical information
Principal Investigator:	Gibson, Professor AP
Other Investigators:
Researcher Co-Investigators:
Project Partners:	UCL
Department:	Medical Physics and Biomedical Eng
Organisation:	UCL
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2004	Ends:	30 September 2007	Value (£):	50,578
EPSRC Research Topic Classifications:	Image & Vision Computing Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 28 May 2003 Engineering Advanced Fellowships Interview Panel Deferred 02 May 2003 Engineering Fellowships Sift Panel 2003 Deferred
Summary on Grant Application Form
In optical tomography of the neonatal head and breast, near infrared light illuminates the body and transmitted light is measured at multiple points on the surface. Optical tomography can generate images of blood volume and oxygenation quantitatively due to the different absorption spectra of oxy- a deoxygenated haemoglobin. The quantitative accuracy, however, depends on the spatial resolution due to the partial volume effect.I will use a priori information from magnetic resonance imaging (MRI) to constrain the optical image reconstruction. This will improve the spatial, resolution and provide the first quantitatively accurate 3D in vivo optical tomography images. I will obtain simultaneous MR and optical images modifying our existing hardware and then use anatomical information from MRI to condition the optical modelling and image reconstruction. I will al develop a system for using generic a priori information so that optical tomography can be performed at the bedside without requiring a patient-speci MR image, providing a safe, portable system for obtaining quantitative images of blood volume and oxygenation. This will be invaluable in neona intensive care, where babies are generally too ill to be moved, and it will allow suspicious breast lesions to be identified without requiring a biopsy.
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