| EPSRC Reference: |
GR/S53480/01 |
| Title: |
Synthesis of the Thiopeptide Antibiotic Nosiheptide, a Heterocyclic Peptide Macrocycle |
| Principal Investigator: |
Moody, Professor CJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
10 November 2003 |
Ends: |
31 July 2005 |
Value (£): |
240,272
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The target of this proposal, the antibiotic nosiheptide, is a member of the thiopeptide family of antibiotics, a growing class of sulfur containing modified cyclic peptides with pronounced biological activity against Gram-positive bacteria and, anaerobes, including pathogens resistant to agents in current use, and also against the malaria parasite. The thiopeptides are of major biological significance; most are powerful inhibitors of protein synthesis in bacteria with novel modes of action.The planned synthesis combines new chemistry (Diels-Alder reactions of vinyloximes) with chemistry pioneered in our own laboratory (carbene N-H insertion, chiral oxime ethers) to obtain the key fragments of the natural product - a 2,3,4-trisubstituted indole, a 2,3,5,6-tetrasubstituted pyridine, and two thiazole containing fragments, which are subsequently coupled together into the double macrocyclic array of nosiheptide.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |