| EPSRC Reference: |
GR/S41463/01 |
| Title: |
Novel in situ Oxidation-Heteroannulation Tandem Processes using Microwave Irradiation |
| Principal Investigator: |
Bagley, Professor M |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2003 |
Ends: |
30 September 2006 |
Value (£): |
108,186
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
Design of Process systems |
| Energy Efficiency |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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Tandem processes and multiple-component reactions offer great facility for the development of highly efficient transformations in synthetic chemistry. This proposal twins these advantages with the energy efficiency of microwave dielectric heating in a focussed monomodal microwave reactor. In situ oxidation under microwave-assisted conditions will generate alkynone or carbonyl-containing intermediates that participate in heteroannulation reactio for the synthesis of pyrimidines, pyridines, azoles, quinolines, pterins and pyrido[2,3-d]pyrimidines in a single synthetic step. These highly facile routes developed and optimized using a standing wave cavity will be transferred to new flow-through irradiation vessels, using batch or continuous flow processing systems, and developed to facilitate the introduction of new greener technologies in process chemistry in the future, as instrumentation advances. Microwave irradiation flow cells, including those that employ a catalyst bed, will be applied to a variety of cascade sequences for the synthesis of heterocyclic building blocks, folate antagonists and diverse libraries from a single propargylic alcohol subset. The transfer from laboratory to flowthrough processing will establish these clean chemical and energy efficient technologies for the assembly of a diverse range of heterocycic targets.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |