| EPSRC Reference: |
GR/S41203/01 |
| Title: |
Genealogies in fluctuating population: the effect of selection |
| Principal Investigator: |
Barton, Professor N |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Inst of Cell, Animal and Population Biol |
| Organisation: |
University of Edinburgh |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
14 November 2003 |
Ends: |
13 November 2006 |
Value (£): |
154,316
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| EPSRC Research Topic Classifications: |
| Mathematical Analysis |
Population Ecology |
| Statistics & Appl. Probability |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Natural selection is likely to act weakly at a large number of sites in the genome. There is currently great interest in understanding the effects of this selection on DNA sequence variation, and conversely, in using sequences to make inferences about population history and biological function. Current methods for analysing the effects of selection on genetic variation are intractable, both analytically and numerically. We have developed a straightforward way of coupling a diffusion approximation for the whole population to the coalescent process that describes the ancestry of samples of genes. We will use this to undestand the effects of selection at multiple loci both on individual loci and on continuous genomes. This will give a solid foundation for the development of improved ways for making inferences from DNA sequence data.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ed.ac.uk |