| EPSRC Reference: |
GR/S41050/01 |
| Title: |
Nonlinear Mathematical Control Theory with Applications to HIV/AIDS Treatment |
| Principal Investigator: |
Zinober, Professor ASI |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Mathematics and Statistics |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
30 November 2004 |
Value (£): |
9,779
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| EPSRC Research Topic Classifications: |
| Medical science & disease |
Non-linear Systems Mathematics |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed project investigates some of the system theoretical problems in nonlinear mathematical control theory identified in the preliminary study of the modelling and control of HIV/AIDS, and applies the developed control techniques to the antiviral therapy of the disease. The main research activities will be centred around the following topics: nonlinear identifiability and identification of HIV/AIDS parameters, feedback control of HIV antiviral therapy, and finite input value control. The proposed programme can be divided into a number of theoretical tasks which will be studied individually. In particular, the feedback control of HIV antiviral therapy will be broken into feeback linearization of the HIV/AIDS models, sliding mode controller design to tackle large model and parameter uncertainty, and output feedback design, by taking into consideration currently available clinical measurements. In the finite input value control problem, the emphasis will be on periodic solutions, fractal sets and chaotic behaviours of the system under such controls.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |