| EPSRC Reference: |
GR/S31440/01 |
| Title: |
NEW METHODOLOGIES FOR MEDIUM-SIZED NITROGEN-CONTAINING RINGS (WITH INITIAL APPLICATIONS) |
| Principal Investigator: |
Murphy, Professor JA |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2004 |
Ends: |
31 December 2006 |
Value (£): |
227,624
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal presents three novel types of methodology which relate to fragmentation reactions to form medium-sized nitrogen,heterocycles. The new reactions should have general applicability to medium-ring amines and amides and are based on (i) modified Schmidt reactions of azides and (ii) fragmentative rearrangements of nitrone triflates and (iii) electron-transfer reactions of azides. The aim is to determine the scope of these new processes and to apply them to the synthesis of a key compound, cleavamine 23, the parent compound forthe Northern fragment of vinblastine and related clinically important anti-cancer drugs.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |