| EPSRC Reference: |
GR/S30269/01 |
| Title: |
The Liliaceae - a potential source of new anti-tubercular drug-leads |
| Principal Investigator: |
Gibbons, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Pharmacy |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
27 October 2003 |
Ends: |
26 October 2006 |
Value (£): |
86,789
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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30 Jan 2003
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Chemistry Prioritisation Panel (Science)
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Deferred
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Summary on Grant Application Form |
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The World Health Organisation has estimated that tuberculosis kills over two million people each year and represents a global epidemic that is worsening due to the occurrence and proliferation of strains of multidrug-resistant (mdr) Mycobacterium tuberculosis. New agents are urgently needed to meet the threat of mdr tuberculosis and to manage infection with the naturally resistant non-tuberculosis fast growing mycobacteria. Outbreaks in major cities such as New York, and more recently in a School in Leicester in the UK, highlight the need for new chemistry for what was previously regarded as a third-world problem.This research proposal seeks funding to investigate the anti mycobacterial properties of extracts from plants belonging to the genus Allium, which we have shown to have good activity against Mycobacterium fortuitum, a model assay for the characterisation of anti-tubercular drugs. Research will focus on the isolation and characterisation of compounds that have activity against a panel of fast growing strains of Mycobacterium, and pure compounds will be evaluated against strains of M. tuberculosis, at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF), in Birmingham, Alabama, USA. Most importantly, the proposed research will train a student in the interdisciplinary subject of Phytochemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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