| EPSRC Reference: |
GR/S15761/01 |
| Title: |
Efficient Total Synthesis of Hemibrevetoxin B by Development of New Strategies for Polyether Construction |
| Principal Investigator: |
Clark, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2003 |
Ends: |
30 September 2006 |
Value (£): |
239,632
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed research project will concern the synthesis of hemibrevetoxin B, the smallest member of the brevetoxin family. Although hemibrevetoxin B is significantly smaller than the other brevetoxins, it is a formidable synthetic target possessing four fused cyclic ethers and 10 stereogenic centres. In addition, it presents many of synthetic challenges found in larger congeners. Hemibrevetoxin B is a popular synthetic target but only a small number of rather lengthy total syntheses have been reported and a short and efficient synthesis has yet to be completed.This proposal outlines our plans to explore both linear and two-directional strategies for the synthesis hemibrevetoxin B using our recently developed ring-closing metathesis methodology for rapid ring construction. Both approaches should deliver hemibrevetoxin B with a longest linear sequence of less than 30 steps from readily available starting materials. If time permits, a third convergent approach based on fragment coupling will be explored.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |