| EPSRC Reference: |
GR/S08992/01 |
| Title: |
Spectroscopic investigations of chiral and induced chiral interactions in molecular aggregates |
| Principal Investigator: |
Howard, Professor BJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
31 March 2006 |
Value (£): |
114,991
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Structure |
| Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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The stereo-specificity of the interactions between chiral molecules will be investigated using high resolution rotational spectroscopy of weakly bound complexes formed between chiral (or potentially chiral) molecules. Species involved will contain -OH and -NH2 groups to model biological systems. The spectra of these species will enable the determination of the structure of the complex and hence the geometry of the potential minimum. Centrifugal distortion effects will provide information on the strength of the intermolecular bond.. Together these measurements should permit direct compariison of homochiral and heterochiral interactions.Since the spectra are likely to be complicated (with many monomer conformers present and with many rotational energy levels populated) significant simplifications can be obtained by observing the lower rotational transitions at low frequencies. For this purpose we plan to construct a novel low frequency microwave fourier transform spectrometer based on an enclosed cavity resonator.Considerable use will be made of high quality ab initio calculations to help interpret the spectra and to further investigate the stereo-specific nature of the intermolecular interactions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |