| EPSRC Reference: |
GR/S03171/01 |
| Title: |
Two-Directional Synthesis: Desymmetrisation Based on the Use of Two Chiral Auxillaries |
| Principal Investigator: |
Stockman, Professor RA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
31 March 2006 |
Value (£): |
85,551
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Two-directional synthesis and tandem reactions offer the possibility of substantially reducing the number of chemical reactions required to synthesise complex target molecules of biological and material interest. In this proposal we will investigate a number of tandem reactions, the substrates of which will be synthesised through a two-directional strategy. This will allow very direct routes into a number of bicyclic systems found in many natural product classes, such as pyrrolizidine, quinolizidine, indolizidine, Stemona and Croomiacea alkaloids. The use of terminal chiral auxillaries to control stereochemistry will be investigated. Ultimately the two-directional synthesis/tandem reaction strategy will be applied to a biologically interesting natural product synthesis. The synthesis of gephyrotoxin, a neurotoxin isolated from a Colombian frog, will use a double Michael addition of a C-2 symmetric acyclic dienoate as the key step to generate the indolizidine core of the natural product.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |