Details of Grant 

EPSRC Reference:	GR/R77582/01
Title:	Understanding the Behaviour of Biomedical Implants: Investigation of Model Surfaces and their Interactions
Principal Investigator:	Jones, Dr FH
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Eastman Dental Institute
Organisation:	UCL
Scheme:	Advanced Fellowship (Pre-FEC)
Starts:	01 April 2002	Ends:	30 August 2006	Value (£):	236,279
EPSRC Research Topic Classifications:	Biomaterials Surfaces & Interfaces
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:	Panel Date Panel Name Outcome 23 Nov 2001 Engineering Fellowships Panel (2002) Deferred
Summary on Grant Application Form
A fellowship is sought, to be held jointly in the Eastman Dental Institute and the Chemistry Department at UCL. The research to be undertaken deals essentially with fundamental aspects of the surface chemistry of model dental and orthopaedic implant materials based on titanium. The overall aim is to gain an understanding some of the important physico-chemical and biological processes that occur after implantation into the body. The proposed project is based on recent work initiated by the applicant, which has demonstrated that cellular response to titanium is influenced by the surface chemistry. Numerous parameters are thought to govern cellular response to a surface, including interactions between the surface and species such as water, hydrated inorganic ions and biomolecules. The specific interactions and their relative importance remain relatively poorly understood. This project therefore aims to build on the previous work to gain a more in-depth understanding of these interactions and the role that surface chemistry plays in controlling them. This will be achieved via the application of powerful surface analysis techniques alongside methods employed more widely in biomaterials research. Ultimately, this project is intended as a step towards the fabrication of surfaces which promote a specific desirable tissue response, in line with the EPSRC's current focus on research at the life sciences interface, which includes biomaterials and tissue engineering.
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