| EPSRC Reference: |
GR/R62366/01 |
| Title: |
Mass Activated Fraction Collection for Organic Chemistry. |
| Principal Investigator: |
Ley, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
JREI |
| Starts: |
01 April 2002 |
Ends: |
31 March 2005 |
Value (£): |
40,281
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Biology |
| Chemical Synthetic Methodology |
Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The equipment requested will underpin the activity of 45 PhD and post doctoral workers in the following areas:Total synthesis of biologically active natural products.Complex carbohydrates and GPI analogues as biological probesCombinatorial chemistry and polymer supported reagentsButane- 1,2-Diacetals: New building blocks for asymmetric synthesisThe chemistry of 7c-allyltricarbonyliron lactone complexesThe primary aim of the group is the development of new synthetic methods and their application to the synthesis of biologically important molecules. We are developing new enabling methods for complex oligosaccharide synthesis and preparing a number of analogues of GPI anchors to be used as biological probes. A key aspect of recent work within our group has focused on the utility of polymer supported reagents in organic synthesis. The application of these reagents offers tremendous opportunities for multi-step synthesis and solution phase library generation. We are working on the use of butane-1,2-diacetals to generate of low carbon count building blocks for asymmetric synthesis. The chemistry of 7t-allyltricarbonyliron lactone complexes is under investigation to develop these complexes as chiral templates for remote asymmetric induction
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |