Details of Grant 

EPSRC Reference:	GR/R59496/01
Title:	NMR methods for measurement of residual dipolar couplings for conformational analysis of carbohydrates
Principal Investigator:	Uhrin, Professor D
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Chemistry
Organisation:	University of Edinburgh
Scheme:	Fast Stream
Starts:	01 December 2001	Ends:	31 May 2003	Value (£):	61,534
EPSRC Research Topic Classifications:	Carbohydrate Chemistry Chemical Structure
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
A better understanding of intermolecular interactions of carbohydrates requires a thorough description of their three-dimensional structures. In this area of chemistry, NMR spectroscopy in combination with computational methods, is the principle experimental technique. A number of NMR parameters, including nuclear Overhauser effect and various scalar coupling constants are used in conformational analysis of carbohydrates. It is however clear that more information is required to describe the large number of conformational degrees of freedom present in carbohydrates. One such class of NMR parameters, which can provide more experimental restraints, are the residual dipolar coupling constants observed in dilute liquid crystalline media. The size of dipolar coupling constants is related to the distance between interacting dipoles, as well as to the orientation of the internuclear vector with respect to a common molecular axis, hence providing a long-range structural sensor.This project looks at NMR methods for accurate and precise measurement of proton-proton, long-range and one-bond proton-carbon dipolar coupling constants, which can be applied to a wide range of strengths of magnetic alignments in carbohydrate samples with natural abundance of 13C isotope. The results of this research will provide reserchers in chemistry and biology with specialized NMR tools and will contribute to better description of molecular structures.
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