| EPSRC Reference: |
GR/R42832/01 |
| Title: |
Chiral Selenium Electrophiles on Solid-Support |
| Principal Investigator: |
Wirth, Professor T |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 June 2001 |
Ends: |
31 May 2004 |
Value (£): |
63,508
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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In this research project steroselective oxidation reactions of not or only weakly activated C=C bonds are investigated. Chiral selenium compounds as described in the proposal are easily accessible and very versatile reagents for these reactions. We could already show that high steroselectivites are obtained with very simple reagents in homogenous phase. Further improvements lie in the design of selective reagents for a broader range of substrates. Ths synthesis of efficient polymer-bound reagents with all the advantages in handling and work-up is the main part of this proposal. Suitable precuror molecules have already been developed and their function as reagents on solid-support has to be investigated. After optimization of selectivities and yields with the polymer-bound reagents their efficient recycling has to addressed. Subsequent applications of this methodology to the synthesis of natural products like the furouran lignans are a further point of interest.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |