| EPSRC Reference: |
GR/R42757/01 |
| Title: |
Enantioselective Receptors through Combinatorial Chemistry |
| Principal Investigator: |
Davis, Professor A |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2002 |
Ends: |
31 January 2005 |
Value (£): |
257,892
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| EPSRC Research Topic Classifications: |
| Combinatorial Chemistry |
Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The design of enantioselective receptors, capable of distinguishing between differently handed molecules, as an important and difficult challenge in supramolecular chemistry. The aim of this project is a system for discovering such receptors, initially for carboxylate anions but generalisable in principle to a wide variety of substrates. The receptors will be variants of a tripodal structure, derived from a steroidal natural product, which has already proved moderately effective. Combinatorial chemistry will be used to generate a large number of related structures bound to small resin beads. The beads will then be subjected to a novel screening process, which will allow isolation of those bearing the most selective receptors. The successful receptors will be identified by mass spectrometric analysis, resynthesized on a larger scale, and subjected to full investigation. Given the range of structures to be surveyed, there is a good chance of discovering highly selective receptors, perhaps for several substrate classes. The research could be useful to areas of the chemical industry, such pharmaceuticals, which must produce compounds in enantiomerically pure form. The receptors could be used in methods for enantiomer seperation ( resolvein machines or simulated moving beds ) where their high selectivities would confer great advantages.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |