| EPSRC Reference: |
GR/R40869/01 |
| Title: |
Flow infra red linear dichroism to determine relative orientations of non-covalent biomacromolecular systems |
| Principal Investigator: |
Rodger, Professor A |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Warwick |
| Scheme: |
ROPA |
| Starts: |
24 July 2001 |
Ends: |
23 January 2004 |
Value (£): |
38,302
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| EPSRC Research Topic Classifications: |
| Chemical Structure |
Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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Summary on Grant Application Form |
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The new technique of infrarted flow linear dichroism (IRFLD) will be developed to detarmine relative orientations of biologicdal macromolecules and their substrates or environments. This will achive the advantages of UV - visible FLD without the disadvantage of scattering and the need for UV-visible chromophores. Challanges with IR include: high concentrations, small pathlengths, water absorbance, and less-robust transparent materials We believe these problems can now be overcome. IRFLD will be tested on our metallohelicate/DNA systems where IR is the simplest means of confirming non-backbone binding. Flow orienting thylakoid membrane proteins in lipid bicelles is also proposed together with a range of other applications.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.warwick.ac.uk |