| EPSRC Reference: |
GR/R39528/01 |
| Title: |
Ring Contraction by Radical ipso-Subitution for The Synthesis of Alnusone, Cavicularin and Riccardin C. |
| Principal Investigator: |
Harrowven, Professor DC |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
60,933
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The programme seeks to develop a transannular ring contraction strategy triggered by the addition of an aryl radical to an arene. Once demonstrated the reaction will be-applied in the synthesis of some biaryl containing macrocyclic natural products. Two classes will be targeted - the alnusones, which have a meta-bridged biphenyl constrained within a thirteen membered carbocycle - and the macrocyclic bis(benzyls), which contain four oxygenated arenes within a strained macrocyclic core.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |