| EPSRC Reference: |
GR/R32970/01 |
| Title: |
Conformational Studies of Biomolecular Ligand-Receptor Interactions By Tandem Ion Trap/Ion Mobility Spectrometry |
| Principal Investigator: |
Creaser, Professor C |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry and Physics |
| Organisation: |
Nottingham Trent University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
19 November 2001 |
Ends: |
18 May 2004 |
Value (£): |
121,269
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Biology |
| Chemical Structure |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This project seeks to exploit the unique capabilities of tandem ion trap/ion mobility spectrometry, to probe conformational changes resulting from non-covalent ligand-receptor interactions of biomolecules and to relate these to their gas and solution phase structures. In tandem ion trap/ion mobility spectrometry, the ion trap may be operated as a conventional mass analyser or as an ion source for the ion mobility spectrometer. For ion mobility measurements, pulses of ions mass-selected in the ion trap are transferred to a drift tube maintained at a constant pressure of helium (-1-6 Ton-). The mobility of an ion is given by the time taken for the ion to traverse the drift tube under the influence of an electric field gradient and is determined by the ion coMsion cross section (i.e. the structure and conformation of the ion). Tandem ion trap/ion mobility measurements, supported by molecular modelling studies, will be directed towards elucidating the gas and solution phase conformations of ligand-receptor complexes of amino acid and peptide ligarxis with polyether and with glycapeptide antibiotic receptors.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ntu.ac.uk |