| EPSRC Reference: |
GR/R29260/01 |
| Title: |
Controlled-Structure Water-Soluble Copolymers of Biomedical Relevance Via Aqueous ATRP |
| Principal Investigator: |
Armes, Professor SP |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sussex |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 November 2004 |
Value (£): |
168,780
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Drug Formulation & Delivery |
| Materials Characterisation |
Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Chemicals |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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The Sussex Polymer Group are world leaders in the development of Atom Transfer Radical Polymerisation (ATRP) for the efficient polymerisation of hydrophilic monomers in aqueous media. We wish to exploit this expertise for the synthesis of a wide range of novel, controlled-structure copolymers of biomedical relevance. These include phosphorylcholine methacrylate-based copolymers, glycerol methacrylate-based copolymers, glycomethacrylatebased copolymers, fully-branched analogues of PEO-PPO diblock and triblock copolymer surfactants; sulfate-based copolymers. Synthetic approaches to diblock and triblock copolymers include use of well-defined macro-initiators, sequential monomer addition and the use of commercially available bifunctional initiators. These copolymers will be evaluated in terms of their biocompatibility, their propensity for forming well-defined micelles via reversible self-assembly and their ability to modify the crystal habit of inorganic materials such as barium sulfate. Characterisation techniques include: proton NMR spectroscopy (for copolymer compositions and monitoring micelle formation); aqueous GPC (for molecular weight distributions); dynamic light scattering (far micelle sizing); electron microscopy (for micelle sizing and barium sulfate particle morphology). Four UK-based companies (Unilever Research, Avecia, Biocompatibles International and Laporte Performance Chemicals) and two UK academics (Prof. A. W. Lloyd and Dr. F. C. Meldrum) are potential beneficiaries of this research programme (see Letters of Support).
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.sussex.ac.uk |